Article Navigation
- Next >
Journal Article
Get access
, Tom Treasure Clinical Operational Research Unit, Department of Mathematics, University College London, London WC1H 0BT, Corresponding author. Clinical Operational Research Unit, University College London, London WC1H 0BT, UK. Tel: 0044 (0)7957 168754; e-mail: tom.treasure@gmail.com (T. Treasure). Search for other works by this author on: Oxford Academic Fergus Macbeth Centre for Trails Research, Cardiff University, Cardiff CF14 4YS, UK Search for other works by this author on: Oxford Academic Lesley Fallowfield Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0001-9358-7610 European Journal of Cardio-Thoracic Surgery, Volume 65, Issue 6, June 2024, ezae216, https://doi.org/10.1093/ejcts/ezae216
Published:
13 June 2024
Article history
Received:
10 May 2024
Accepted:
24 May 2024
Published:
13 June 2024
- Views
- Article contents
- Figures & tables
- Video
- Audio
- Supplementary Data
-
Cite
Cite
Tom Treasure, Fergus Macbeth, Lesley Fallowfield, A prospective multicentre cohort study of colorectal lung metastasectomy with a nested randomized controlled trial: the key points from the pulmonary metastasectomy in colorectal cancer study, European Journal of Cardio-Thoracic Surgery, Volume 65, Issue 6, June 2024, ezae216, https://doi.org/10.1093/ejcts/ezae216
Close
Search
Close
Search
Advanced Search
Search Menu
Extract
We were interested to read the large retrospective analysis of the results of pulmonary metastasectomy from 15 European thoracic surgical centres [1]. The authors refer to a ‘much debated’ randomized controlled trial (RCT) which ‘disclosed no survival benefit of PM over non-surgical treatment’ and cite the PulMiCC trial (pulmonary metastasectomy in colorectal cancer) [2]. In their detailed analysis of 1647 patients over nearly a decade, more than half had colorectal cancer (CRC) and so PulMiCC is directly relevant. We thank the authors for referencing our work and are pleased to take the opportunity to summarize its findings (Fig.1) and to comment on their significance with respect to the multicentre retrospective analysis of pulmonary metastasectomy.
The idea of a trial of to test the clinical effectiveness of lung metastasectomy was formally proposed during the launch of the Lung Metastasectomy Project at the 2006 European Society of Thoracic Surgeons annual meeting [3]. There were already many retrospective analyses [4], and there have been many more since [5], none with contemporaneous controls showing the survival rate for similar patients who did not have their metastases resected. To capture this information the PulMiCC study was designed with 2 distinct phases. Patients who had their primary colorectal cancer resected, and were potential candidates for lung metastasectomy, were recruited from 2010 to 2017 in 25 clinical sites, after written informed consent. Of 512 volunteers, 93 agreed to randomization and 28 had non-CRC nodules, leaving an observational cohort of 391. Their survival is depicted in the upper panel of the figure. Using the same selection factors as were available internationally, teams elected to operate on 263 of them. Their survival (upper curve) is similar to the retrospective multicentre analysis [1]. The PulMiCC elective cohort also shows the survival of patients who did not have metastasectomy (red line). Note that the consensus assumption of the American Society of Thoracic Surgeons—that survival was probably nil without operation [5]—was disproved.
Subject
Lung Minimally Invasive Procedures (Thoracic)
Issue Section:
Editorial
You do not currently have access to this article.
Download all slides
Sign in
Get help with access
-
European Association for Cardio-Thoracic Surgery members
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Institutional access
- Sign in with a library card
- Sign in with username/password
- Recommend to your librarian
Sign in through your institution
Sign in through your institution
Institutional account management
Sign in as administrator
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Subscription prices and ordering for this journal
Purchasing options for books and journals across Oxford Academic
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
A prospective multicentre cohort study of colorectal lung metastasectomy with a nested randomized controlled trial: the key points from the pulmonary metastasectomy in colorectal cancer study - 24 Hours access
EUR €39.00
GBP £34.00
USD $42.00
Rental
This article is also available for rental through DeepDyve.
Advertisem*nt intended for healthcare professionals
Citations
Views
6
Altmetric
More metrics information
Metrics
Total Views 6
5 Pageviews
1 PDF Downloads
Since 6/1/2024
| Month: | Total Views: |
|---|---|
| June 2024 | 6 |
Citations
Powered by Dimensions
Altmetrics
Email alerts
Article activity alert
Advance article alerts
New issue alert
In progress issue alert
Subject alert
Receive exclusive offers and updates from Oxford Academic
Citing articles via
Google Scholar
-
Most Read
-
Most Cited
More from Oxford Academic
Cardiothoracic Surgery
Medicine and Health
Surgery
Books
Journals
Advertisem*nt intended for healthcare professionals
